川崎病冠状动脉病变发病机制的新认识

摘要

Kawasaki disease(KD)is an acute febrile rash illness with systemic small and medium-sized vessel Vasculitis in children,which it is fealured by wide polyangitis,especially that lesion of cardiovascular system is severe,and it can form coronary arterictasis and coronaty artery aneurysm (CAA).Mechanisms of KD with coronary artery lesion(CAL)are still unclear at present,Abnormal activation and cell infiltration of the immune system in the coronary arteries,coronary endothelial dysfunction and lesion,genetic factors especially gene polymorphisms of CRP,TNFa,VEGF,MMPs and so on.perhaps patricpate in it’s pathogenesis,which is attracting more attention.%　　川崎病是一种以全身中小血管炎为主要病变的急性发热性出疹性小儿疾病。特征性的广泛的中小血管炎症,以心血管系统损害严重,可形成冠状动脉扩张和冠状动脉瘤。目前,发病机制尚不清楚,免疫系统异常活化及细胞浸润,冠状动脉内皮损伤及功能紊乱,遗传因素,特别是C反应蛋白,肿瘤坏死因a,血管内皮生长因子,基质金属蛋白酶等的基因多态性可能参与发病,值得高度关注。