多系统萎缩16例临床分析

摘要

目的：探讨多系统萎缩（MSA）的临床特点、影像学特征，以利于早期诊断，减少误诊率。方法：回顾性分析16例MSA患者临床资料。结果：拟诊MSA 11例，可能MSA 5例，其中橄榄桥脑小脑萎缩（MSA-OPCA）9例，纹状体黑质变性（MSA-SND）4例，Shy-Drager综合征（MSA-SDS）3例，MRI表现上OPCA患者以小脑、脑桥、延髓萎缩为主，SND主要病变在壳核，SDS个别有小脑萎缩。结论：临床表现和MRI结合可提高MSA的诊断率。%Objective:To analyze clinical manifestations and neuroimage for early diagnosis of multiple system atrophy(MSA).Method:Clinical materials of 16 MSA cases were retrospectively analyzed.Result:11 cases were probably diagnosed as MSA,another 5 cases were possible MSA.Among the 16 cases,9 cases were olivopontocerebellar atrophy(OPCA),4 cases striatonigral degeneration(SND),and 3 cases were Shy-Drager syndrome(SDS).MRI showed that main lesion of OPCA were in cerebellum,pons,medulla,SND in putamen. and partial SDS in cerebellum. Conclusion:The diagnostic accordance rate of MSA can be elevated with correlation between clinical manifestations and brain MRI.