肥胖儿童血清25羟维生素D及胰岛素抵抗研究

摘要

Objective:To investigate the relationship between childhood obesity and serum 25-(OH)D concentration and insulin resistance.Method:60 obese children aged 7 to 14 and 60 cases of normal weight children were selected. A fasting blood test was taken on serum 25-(OH)D concentrations,blood glucose and insulin. HOMA-IR was used to assess the level of insulin resistance. Tthe difference of serum 25-(OH)D concentration and insulin resistance was compared in the two groups.Result:The serum 25-(OH)D concentration of obese children was lower than that of normal children(P<0.01). HOMA-IR of obese children was higher than that of normal children. The difference was statistically significant(P<0.01). 25-(OH)D was negatively correlated with HOMA-IR(r=0.596,P<0.01). Conclusion:The serum 25-(OH)D concentration of obese children is lower than that of normal children. The level of insulin resistance of obese children is higher than that of normal weight children. Monitoring serum 25-(OH)D concentration in obese children and supply them with vitamin D is conductive to the improvement of insulin resistance and weight reduction.%目的：探讨儿童肥胖与血清25羟维生素D[25-（OH）D]及胰岛素抵抗的关系。方法：选取7~14岁肥胖儿童60例及正常体重儿童60例，抽血检测空腹血清25-（OH）D、血糖及胰岛素水平，采用胰岛素抵抗指数（HOMA-IR）评估胰岛素抵抗水平。比较两组血清25-（OH）D及胰岛素抵抗水平的差异。结果：肥胖儿童组血清25-（OH）D显著低于正常体重儿童组（P<0.01）；肥胖儿童组HOMA-IR高于正常体重儿童组，差异有统计学意义（P<0.01）；25-（OH）D与HOMA-IR呈负相关（r=-0.596，P<0.01）。结论：肥胖儿童血清25-（OH）D低于正常儿童，且胰岛素抵抗水平高于正常体重儿童，对肥胖儿童监测25-（OH）D并适当补充维生素D，有利于改善胰岛素抵抗，减轻体重。