糖尿病酮症酸中毒患者血清CA19-9水平的变化

摘要

目的：回顾性观察糖尿病酮症酸中毒患者血清CA19-9水平，分析糖尿病急性代谢紊乱状态下CA19-9升高的特点。方法：选取糖尿病酮症酸中毒患者73例和血糖控制差（糖化大于7.5%）的糖尿病非酮症酸中毒患者209例，对其性别、年龄、糖尿病病程、体重指数、HbA1c、CA19-9水平进行分析。结果：（1）酮症酸中毒组平均CA19-9水平29.7（57.8~15.35）U/mL，显著高于非酮症酸中毒组10.1（19.65~5.40）U/mL，比较差异有统计学意义（P<0.01）；前者CA19-9升高的比例为39.7%，而后者为7.7%（P<0.01），两者比较差异有统计学意义。（2）CA19-9升高的45例患者中数值在200 U/mL以内者占95.6%，其中10例患者病情纠正后复查CA19-9均呈下降趋势。结论：糖尿病患者CA19-9水平在酮症酸中毒状态下较非酮症酸中毒状态下可更明显升高。%Objective:To retrospectively observe the alteration of serum CA19-9 levels in patients with diabetic ketoacidosis(DKA)compared to diabetics without DKA. Method:Seventy-three patients with DKA(DKA group)and 209 diabetics under dissatisfied glucose control(non-DKA group,HbA1c>7.5%)were enrolled. Records of gender,age, diabetic duration,BMI,HbA1c,CA19-9 level were collected. The levels of serum CA19-9 were compared between the two groups. Result:(1)Average CA19-9 level was significantly higher in DKA group 29.7(57.8-15.35)U/mL than that in non-DKA group 10.1(19.65-5.40)U/mL(P<0.01),as well as the percentage of positive CA19-9 level(39.7%and 7.7%,P<0.01).(2)The abnormal values were in range of 37.1-674.5 U/mL,mainly distributed within 200 U/mL(95.6%). Conclusion:Slight to moderate elevations of CA19-9 levels are more frequently found in DKA patients than diabetics under poor glucose control,as well as significant higher levels.