牙周炎对2型糖尿病患者血清和龈沟液IL-6含量影响的研究

摘要

Objective: To detect the effect of Periodontitis on the concentration of IL-6 in serum and gingival crevicular fluid in type 2 diabetic patients.Method: Twenty patients with type-2 diabetes and periodontitis, 20 with simple type-2 diabetes, 20 with simple periodontitis and 16 healthy patients were recruited in this study. The concentration of IL-6 in serum and gingival crevicular fluid were detected by Enzyme Linked Immunosorbent Assay (ELISA), the difference of IL-6 content in serum and gingival crevicular fluid were compared among groups, the correlation between the concentration of IL-6 in serum and that in gingival crevicular fluid were analyzed within group.Result: The concentration of IL-6 in serum and gingival crevicular fluid in three unhealthy groups were significantly higher than that in the healthy group (P<0.001).The concentration of IL-6 in serum and gingival crevicular fluid of the patients with type-2 diabetes and periodontitis were higher than that of the patients just with diabetes or periodontitis. There was a positive correlation between the concentration of IL-6 in serum and that in gingival crevicular fluid respectively in type-2 diabetes patients with periodontitis group (r=0.829,P<0.01), simple diabetes mellitus group (r=0.766,P<0.01) and simple periodontitis group (r=0.732,P<0.01).Conclusion: The concentration of IL-6 in serum and gingival crevicular fluid in type-2 diabetes patients can be increased by periodontitis, IL-6 may play an important role in the interaction between periodontal disease and diabetes.%目的：探讨牙周炎对2型糖尿病患者血清和龈沟液IL-6含量的影响。方法：采用酶联免疫吸附试验（ELISA）检测20例2型糖尿病伴牙周炎患者、20例单纯2型糖尿病患者、20例单纯牙周炎患者及16例健康者的血清和龈沟液（GCF）中IL-6含量，比较组间血清和龈沟液IL-6含量的差异性，分析组内血清和龈沟液IL-6含量的相关性。结果：2型糖尿病伴牙周炎组、单纯2型糖尿病组及单纯牙周炎组的IL-6含量均明显高于健康组（P<0.001），且2型糖尿病伴牙周炎组高于单纯糖尿病组及单纯牙周炎组；血清和龈沟液IL-6含量在伴牙周炎糖尿病组（r=0.829，P<0.001）、单纯2型糖尿病组（r=0.766，P<0.001）及单纯牙周炎组（r=0.732， P<0.01）均呈正相关关系。结论：牙周炎可提高2型糖尿病患者血清和龈沟液IL-6的含量，IL-6可能在牙周炎与糖尿病之间的双向作用中具有重要意义。