胰高血糖素样肽1及其类似物的脑保护作用

摘要

Glucagon-like peptide 1 is a kind of incretins. Its hypoglycemic effect can be achieved by various ways such as:the promotion of the release of insulin,the inhibition of the secretion of glucagon and the proliferation of isletβcell,the delay of gastric emptying and so on. Clinically,glucagon-like peptide-1 and its analogs have been used for the treatment of type 2 diabetes. In recent years,some studies found that glucagon-like peptide-1 receptor is not only distributed in the pancreas,but also widely distributed in the brain. Glucagon-like peptide-1 and its analogs have the effects to protect the brain suggesting that they may become a new drug for the treatment of central nervous system diseases.%胰高血糖样肽1是一种肠促胰岛素，它通过促进胰岛素的释放，抑制胰高血糖素分泌、胰岛β细胞增殖、延缓胃排空等多种途径发挥降糖作用。在临床上胰高血糖素样肽1及其类似物已用于2型糖尿病的治疗。近年来，研究发现胰高血糖样肽1受体不仅分布于胰腺中，在人和动物的脑中也有广泛分布，胰高血糖样肽1及其类似物具有脑保护作用，预示着他们有可能成为治疗中枢神经系统疾病的新型药物。