银屑病患者外周血白细胞膜CD14及血浆可溶性CD14表达的临床意义分析

摘要

目的：探讨银屑病（PSG）患者外周血白细胞膜CD14及血浆可溶性CD14表达的临床意义分析。方法：选择36例寻常性PSG患者（PSG组）和52例健康体检者（健康对照组），观察和比较两组外周血白细胞mCD14及sCD14表达水平。结果：PSG组患者外周血白细胞膜联mCDl4的表达水平为（6.20±2.20）%，其中进行期、静止期分别为（7.30±2.40）%、（4.70±2.20）%，均较健康对照组明显增高（P<0.01）。PSG组患者外周血白细胞膜sCD14的浓度平均为（1.39±0.38）μg/mL，其中进行期、静止期分别为（1.42±0.39）μg/mL、（1.21±0.44）μg/mL，均较健康对照组显著增高（P<0.01）。结论：外周血白细胞膜CD14及血浆可溶性CD14对银屑病的发病机制、临床诊断等均有重要的意义。同时有助有于进一步探讨PSG发病机制。%Objective:To explore the clinical significance of expression of psoriatic peripheral white blood cell membrane CD14 and plasma soluble CD14 in patients with psoriasis. Method:36 patients with PSG and 52 healthy subjects were collected,expression of psoriatic peripheral white blood cell membrane CD14 and plasma soluble CD14 of two groups were observed and compared.Result:The average expression levels of mCDl4 in white blood cell patients with psoriasis group was(6.20±2.20)%,in which the active phase and stationary phase were(7.30±2.40)%,(4.70±2.20)%respectively. They were significantly higher than the healthy control group and there was significant difference(P<0.05).The average concentration of sCD14 in white cell membrane of peripheral blood of psoriasis patients was(1.39±0.38)μg/mL, in which the active phase and stationary phase were(1.42±0.39)μg/mL,(1.21±0.44)μg/mL respectively. Comparing with healthy control group,the levels significantly increased with significant difference(P<0.05). Conclusion:Diagnostic significance of white blood cell of patients with psoriasis and CD14 plasma soluble CD14 on the pathogenesis of psoriasis diagnosis has important clinical diagnosis. At the same time,help to further explore the pathogenesis of PSG.