罗格列酮联合维生素E治疗非酒精性脂肪性肝病的临床研究

摘要

Objective:To investigate the effect of rosiglitazone combined with vitamin E in the treatment of nonalcoholic fatty liver disease(NAFLD). Method:90 cases of NAFLD with diet control and exercise in our hospital were randomly divided into three groups,30 cases in each gloup.Three groups were treated with rosiglitazone,vitamin E and rosiglitazone combined with vitamin E separately.The course was 6 months.Liver function indexes(ALT,AST,GGT),blood lipid levels(TG),and the improvement situation of NAFLD ultrasound morphology before and after treatment of three groups were compared. Result:The three groups after treatment liver function,blood lipid than before treatment improved(P<0.05),and the liver function(ALT,AST,GGT)improvement was obvious(P<0.01).The three groups after treatment liver function,blood lipid differences were statistically significant(P<0.01),combined liver function group after treatment (ALT,AST,GGT)was better than vitamin E group and rosiglitazone group(P<0.01),TG improvement was better than the other two groups(P<0.05). Vitamin E group,rosiglitazone group,combined group effective rate were 53.33%,66.67%,90%. Combined group compared with rosiglitazone group,χ²=4.812,P<0.05;compared with vitamin E, χ²=9.932,P<0.01. Conclusion:Rosiglitazone combined with vitamin E is safe and effective in the treatment of NAFLD,and combined therapy is better than the single drug therapy.%目的：探讨罗格列酮联合维生素E治疗非酒精性脂肪性肝病（NAFLD）的临床疗效。方法：将本院进行饮食控制和适当锻炼的90例NAFLD患者随机分为三组，每组30例，分别应用罗格列酮、维生素E、罗格列酮联合维生素E三种方法治疗，疗程为6个月。比较治疗前后各组肝功能指标（ALT、AST、GGT）、血脂水平（TG）、NAFLD超声形态学的改善情况。结果：治疗后三组肝功能、血脂较治疗前均有所改善（P<0.05），其中肝功能（ALT、AST、GGT）改善尤为明显（P<0.01）。治疗后三组肝功能、血脂比较差异均有统计学意义（P<0.01），联合组治疗后肝功能（ALT、AST、GGT）改善优于维生素E组及罗格列酮组（P<0.01），TG改善亦优于其他两组（P<0.05）。维生素E组、罗格列酮组、联合组有效率分别为53.33%，66.67%，90.00%；联合组与罗格列酮组、维生素E组比较，差异均有统计学意义（字2=4.812，P<0.05；字2=9.932，P<0.01）。结论：罗格列酮和维生素E联合治疗NAFLD安全有效，且联合治疗的效果要优于单药治疗。