支原体、衣原体感染与不孕症的关系及耐药性分析

摘要

目的：分析人支原体（Mh）、脲脲支原体（Uu）、沙眼衣原体（Ct）与不孕症的关系，并对支原体药敏试验结果进行分析，以指导临床治疗，促进不孕症治疗效果的提升。方法：选取2012年5月-2013年8月在本院门诊收治的220例不孕症患者作为观察组，并选择同期自愿参与本研究的220例正常生育妇女作为对照组，比较两组宫颈分泌物Uu、Mh、Ct检测结果。同时对支原体感染者做药敏实验，了解支原体对抗菌药物的敏感率和耐药性。结果：观察组Ct、Uu、Uu+Mh、Uu+Ct阳性检出率分别为19.54%、36.82%、8.63%、3.18%，与对照组比较差异均有统计学意义（P<0.05）。Uu对米诺环素、多西环素、交沙霉素、环酯红霉素的敏感率较高，均超过了80%。Uu+Mh对米诺环素、多西环素、交沙霉素的敏感率较高，分别为95.0%、85.0%、75.0%。单独Uu感染的耐药性较低，但是Uu+Mh感染的耐药率明显升高，多药耐药情况严重。结论：Uu、Mh、Ct是引起不孕症的主要原因，是不孕症诊断重要的检测项目。对于因Uu、Mh、Ct感染引起的不孕症，要根据药敏试验结果予以针对性的治疗，从而提升治疗效果。%Objective:To analyze the human mycoplasma(Mh),urea urealyticum(Uu),Chlamydia trachomatis (Ct)and the relationship between infertility,and analyze mycoplasma susceptibility test results,to guide clinical treatment and promote the infertility treatment effect.Method:220 infertile women were selected from May 2012 to August 2013 in our hospital as the observation group,220 normal pregnant women who were voluntarily participated in this study were selected as the control group,cervical secretions Uu,Mh,Ct test results of the two groups were compared.At the same time,drug sensitivity test of mycoplasma infection were done,mycoplasma to sensitive rate and antimicrobial resistance were understood. Result:The Ct,Uu,Uu+Mh,Uu+Ct positive detection rates were 19.54%,36.82%,8.63%,3.18%,compared with the control group were statistically significant difference(P<0.05).Uu of minocycline,doxycycline,josamycin,cyclic ester of erythromycin sensitive rate were higher,more than 80%.Uu+Mh of minocycline,doxycycline,josamycin sensitive rate were higher,respectively 95.0%,85.0%,75.0%. Separate Uu infection resistance was low,but Uu+Mh infection was significantly higher resistance,multidrug resistance in serious condition.Conclusion:Uu,Mh,Ct are the main cause of infertility,infertility diagnosis is important to test items.For the result of Uu,Mh,Ct infection caused by infertility, according to the susceptibility test results to the specific treatment,so as to improve the therapeutic effect.