地塞米松联合甘露醇应用于急性重症脑血管病脑保护作用的临床研究

摘要

Objective:To investigate the therapeutic effect of combination therapy with dexamethasone(DXM)and mannitol on acute severe cerebrovascular disease cerebral protective effect. Method:One hundred and sixty patients were randomly divided into the treatment group and the control group,the control group only received routine treatment with combination therapy,the treatment group was given DXM and mannitol on the basis of the control group. The indicators between the two groups were compared after treatment,such as the effective rate,complication. Result:ICP recovery time of the treatment group was significantly shorter than that of the control group after the treatment,but the difference of complications and mortality rate between the two groups in acute stage were no statistically significant(P>0.05). The patients survived more than forty days of the control group was 34 cases while the treatment group was 73 cases after treatment,and the difference between the two groups were statistically significant(P<0.05). Conclusion:DXM and mannitol is stronger in reducing brain edema,decreasing intracranial pressure cerebral protective effect in cerebrovascular disease,and does not increase the incidence of complication and mortality.%目的：探讨地塞米松（DXM）和甘露醇合用对急性重症脑血管病脑保护作用的疗效。方法：将160例患者随机分为治疗组和对照组，每组80例。对照组只行常规治疗，治疗组在对照组基础上给予DXM、甘露醇联用治疗，比较两组疗效及并发症情况。结果：治疗后，治疗组ICP恢复正常时间较对照组显著缩短，但两组并发症及急性期病死率比较差异均无统计学意义（P>0.05）；治疗组重症病例存活超过40 d例数（73例）显著高于对照组（34例），两组比较差异有统计学意义（P<0.05）。结论：在脑血管病中，DXM和甘露醇合用对减轻脑水肿、降低颅内压脑保护作用更强，且不增加其并发症和病死率。