NF-κB与TNF-α在COPD稳定期患者血清中的变化及临床意义

摘要

目的:探讨NF-κB与TNF-α在慢性阻塞性肺病(COPD)稳定期患者血清中的表达水平及临床意义.方法:选取2013年5月-2014年12月本院病理科诊断为COPD的患者108例(COPD组)及同期体检中心健康体检者95例(对照组).用酶联免疫吸附法(ELISA)测定两组血清TNF-α、NF-κB水平.结果:两组年龄、性别比较差异均无统计学意义(P>0.05),而COPD组体重指数(BMI)较对照组偏低,比较差异有统计学意义(P<0.05).与对照组比较,COPD患者TNF-α、NF-κB水平均升高,比较差异有统计学意义(P<0.05).通过直线相关性分析得出,COPD 稳定期患者NF-κB与TNF-α存在正相关趋势(r=0.156, P<0.05).结论:COPD 稳定期患者血清中NF-κB与TNF-α水平升高,可能与COPD患者全身炎症反应有关.%Objective:To discuss the clinical significance and changes of serum NF-κB and TNF-α levels in patients with chronic obstructive pulmonary disease (COPD).Method:From May 2013 to December 2014,108 COPD patients who diagnosed by pathologists were selected as the COPD group,and 95 cases of healthy were selected as the control group. And then serum NF-κB and TNF-α level of two groups were determined by enzyme linked immunosorbent assay (ELISA).Result:There were no statistical significance in age and gender between the two groups(P>0.05). However, COPD group's BMI index showed higher than that in the control group,and there was statistical significance (P<0.05). Compared with the control group, COPD group's serum TNF-αand NF-κB levels showed increased,and the difference were statistically significant (P<0.05).The linear correlation analysis showed that the serum NF-κB level positive correlated with TNF-α level in COPD group(r=0.156,P<0.05).Conclusion:The serum NF-κB and TNF-αlevel of COPD patients are increased,it maybe associated with systemic inflammatory response.