Objective:To investigate the effect of infantile cough mixture for children with cough variant asthma on lung function,serum IgE and peripheral blood EOS.Method:100 children with cough variant asthma in our hospital were selected from October 2010 to October 2013 as the research objects,they were randomly divided into observation group and control group, 50 cases in each group.The control group was given conventional treatment,the observation group on the basis of that was given cough mixture,one day a dose,two groups were in a course of 4 weeks.After treatment,the frequency of cough and cough symptom intensity of two groups were observed and compared,their signs points were recorded;before and after the treatment, the pulmonary function,serum IgE and EOS in peripheral blood of two groups were compared.Result:After treatment,the total effective rate of observation group was higher than the control group,symptoms and lung function improvement were significantly better than the control group,the differences were statistically significant(P<0.05);after the treatment,the patients in the two groups of serum IgE and EOS in peripheral blood were significantly reduced,and the value of measurement of the observation group was significantly lower than the control group,the differences were statistically significant(P<0.05). Conclusion:Children with cough mixture can anti allergic inflammation,reduce airway hyperresponsiveness,significant treatment children cough variant asthma.%目的：探讨小儿肺咳合剂对咳嗽变异性哮喘患儿肺功能、血清IgE及外周血EOS的影响。方法：回顾性选取本院2010年10月-2013年10月收治的100例儿童咳嗽变异性哮喘患者作为研究对象，将其随机分为观察组和对照组，每组各50例。对照组均给予常规治疗，观察组在对照组基础上，同时给予小儿肺咳合剂，1剂/d，两组患者均以4周为一疗程。观察并比较两组患者治疗后的咳嗽频率和咳嗽强度症状、记录他们的体征积分，比较治疗前后两组患者的肺功能和血清IgE及外周血EOS。结果：治疗后，观察组治疗总有效率高于对照组，患儿症状积分及肺功能改善情况均显著优于对照组，两组比较差异均有统计学意义（P<0.05）；治疗后两组患者血清IgE及外周血EOS都得到显著降低，且观察组的测量值明显低于对照组，两组患者的疗效比较差异有统计学意义（P<0.05）。结论：小儿肺咳合剂能抗变应性炎症，降低气道的高反应性，治疗儿童咳嗽变异性哮喘疗效显著。
展开▼
