Efficacy of aerosol budesonide combined with montelukast in treatment of children with cough variant asthma and its influence on lung function indexes and serum inflammatory factor levels

摘要

Objective:To explore the efficacy of aerosol budesonide combined with montelukast in the treatment of children with cough variant asthma (CVA) and its influence on lung function indexes and serum inflammatory factor levels.Methods:A total of 102 CVA children in our hospital were randomly divided into A, B, C group (n=34). Three groups were given conventional symptomatic treatment(like phlegm dispersing, anti-infection). A group was given aerosol budesonide treatment, B group was given montelukast treatment and C group was given aerosol budesonide combined with montelukast treatment. Changes of clinical symptom scores, lung function indexes and inflammatory factor levels were compared between three groups before and after treatment.Results:After treatment, clinical symptom scores and inflammatory factor-IgE, IL-4 and TNF-α levels in C group were significantly lower than before treatment and that in A, B group after treatment (P<0.05); lung function index-FVC, FEV1, PEF levels were significantly higher than before treatment and that in A, B group after treatment (P<0.05). There showed obvious negative correlation between lung function index-FVC, FEV1, PEF and inflammatory factor-IgE, IL-4 and TNF-α.Conclusions:On the basis of conventional symptomatic treatment (like phlegm dispersing, anti-infection), aerosol budesonide combined with montelukast treatment could reduce the inflammatory factor levels, relieve the clinical symptoms, improve the lung function indexes.