抗核抗体、自身免疫性抗体与慢性乙肝的关系及护理对策分析

摘要

Objective:To study relationship and nursing countermeasures of antinuclear antibodies, liver specific autoantibodies with chronic hepatitis B.Method:From March 2013 to March 2014 in our hospital for treatment of 100 cases of patients with chronic hepatitis B (CHB) as the research object.Chose 92 cases in our hospital received physical examination of normal persons as control group, the related antibodies, CHB from positive and negative group of related indicators, nursing care of patients before and after treatment adherence of two groups were compared.Result:Chronic hepatitis B group’s ANA positive rate was 24.00% (24/100), was significantly higher than the control group’s 4.35% (4/92), the difference was statistically significant (P<0.05).CHB group since the positive resistance layer adhesion proteins (LN) and hyaluronic acid (HA), and collagen type Ⅳ levels were significantly higher than the negative resistance groups, differences were statistically significant (P<0.05).Two groups in ALT, AST, HBV quantitative was contrast and HBV parting, there were no statistically significant difference (P>0.05).After nursing of treatment adherence for patients with chronic hepatitis B was significantly higher than before treatment, the difference was statistically significant (P<0.05). Conclusion:There are more antibody in serum of patients with chronic hepatitis b, but the ANA and the prognosis of patients with liver disease related antibody assay for predicting and outcome has great significance, it could be one of the causes of liver cirrhosis after hepatitis B.At the same time, nursing countermeasures for patients and can increase treatment adherence to care, worthy of clinical attention.%目的：研究抗核抗体（ANA）、自身免疫性肝病抗体（LSA）与慢性乙型肝炎的关系及护理对策。方法：选择2013年3月-2014年3月在本院接受治疗的慢性乙肝患者100例作为研究对象（慢性乙肝组），另选92例在本院接受健康体检的正常人员作为对照组。对比两组相关抗体情况，CHB自抗阳性、阴性组相关指标情况，护理前后患者的治疗依从性情况。结果：慢性乙肝组的ANA阳性率为24.00%（24/100），显著高于对照组的4.35%（4/92），差异有统计学意义（P<0.05）。CHB自抗阳性组的层黏连蛋白（LN）和透明质酸酶（HA），以及Ⅳ型胶原水平均显著高于自抗阴性组，差异均有统计学意义（P<0.05）。两组在ALT、AST、HBV定量以及HBV分型等方面比较差异均无统计学意义（P>0.05）。护理后慢性乙肝患者的治疗依从性显著高于护理前，差异有统计学意义（P<0.05）。结论：慢性乙肝患者血清中存在较多抗体，但ANA及肝病相关抗体测定对于预测患者预后和转归具有较大的意义，其可能是导致乙肝后肝硬化的一种病因。同时，为患者制定护理对策并施以护理能增加治疗依从性，值得临床重视。