Adherence of Blood Components to Artificial Kidney Membranes (Anti-Nuclear Antibodies in Chronic Dialysis and Renal Transplantation).

摘要

Because of the presence of free cell nuclei and nuclear remnants adherent to used dialysis membranes,we are studying the incidence of antibodies to nuclear antigens (DNA, ENA,and FANA) in patients with end stage kidney disease,in patients on chronic dialysis,and in patients after kidney transplantation. The incidence of positive patients to date is as follows:end stage kidney disease (pre-dialysis) 7/30 (23.3%),dialysis one to four years 30/116 (25.9%),successful kidney transplantation 5/19 (26.3%),transplantation failure 8/17 (47.0%). No major blood group characteristics have been identified to distinguish the positive group;possible unique HLA-antigen trends are suggested. Patients positive for antibodies have been found in multiple age groups with many types of kidney diseases. There appears to be no difference in the incidence of antibodies in patients who reuse compared to those who do not reuse dialyzers. Rapid changes between antibody positivity and negativity in serial studies suggest the possibility of circulating immune complexes.