儿童A型流感病毒与呼吸道合胞病毒性肺炎血清细胞间黏附分子-1的表达及意义

摘要

目的：探讨儿童A型流感病毒肺炎与呼吸道合胞病毒性肺炎中血清可溶性细胞间黏附分子-1的表达及其意义，以指导临床治疗和预防。方法：选取于本科住院的肺炎儿童，根据逆转录聚合酶链反应结果分为FA组（A型流感病毒阳性）36例，RSV组（呼吸道合胞病毒阳性）22例，同时选取同期来本院体检的健康儿童41例为对照组，分析比较三组儿童的血清sICAM-1值。结果：FA组和RSV组血清sICAM-1值均高于对照组，比较差异有统计学意义（P<0.05）。结论：A型流感病毒肺炎与呼吸道合胞病毒性肺炎儿童中sICAM-1表达水平升高，是导致儿童气道炎症的重要炎症因子之一，可为临床治疗采用抗粘附疗法及抗炎抑制炎性因子提供佐证。%Objective: The expression and significance of serum soluble intercellular adhesion molecule-1 in children with influenza A virus pneumonia and respiratory syncytial virus pneumonia in -1, in order to guide the clinical treatment and prevention.Method: In our hospital from pneumonia in children, according to the reverse transcriptase polymerase chain reaction results were divided into FA group (A influenza virus positive) 36 cases, group RSV (respiratory syncytial virus positive) in 22 cases, at the same time in healthy children at our hospital physical examination 41 cases as control group, serum sICAM-1 were compared between the three groups children’s value.Result: In FA group and RSV group, serum sICAM-1 values were higher than those in the control group, there was significant difference (P<0.05). Conclusion: The expression of A increased the level of sICAM-1 influenza virus pneumonia and respiratory syncytial virus pneumonia in children, which is one of the important inflammatory airway inflammation in children, can provide clinical treatment with anti adhesion therapy and anti-inflammatory, inhibiting inflammatory factors to provide evidence.