地特胰岛素对2型糖尿病患者人体成分的影响

摘要

目的：评价口服降糖药控制不佳的2型糖尿病患者加用地特胰岛素对人体成分的影响。方法：选取2010年2-9月大连市中心医院就诊的27例口服降糖药控制不佳的2型糖尿病患者（均符合1999年WHO的糖尿病诊断标准），在原有治疗方案的基础上加用地特胰岛素6~8 U/d起始治疗，治疗期为3个月，治疗前后分别应用Inbody 720人体成分分析仪进行人体成分分析，同时测定27例患者治疗前后身高、体重、糖化血红蛋白等，并比较治疗前后相关指标的变化。结果：治疗3个月后患者HbA1c较前明显下降，差异有统计学意义（t=5.116，P<0.001）。治疗3个月后体脂百分数较前下降，差异有统计学意义（t=2.161，P<0.05）。治疗3个月后体重、BMI、腰臀比、蛋白质、无机盐、脂肪量、肌肉量、内脏脂肪面积等与治疗前相比，差异均无统计学意义（P>0.05）。结论：对口服药控制不佳的2型糖尿病患者加用地特胰岛素治疗，在血糖明显下降的同时，体重呈下降趋势，其中肌肉量无明显变化，但体脂肪比例明显下降。%Objective:To evaluate the effect of once-daily Insulin Detemir on the body composition in poorly controlled type 2 diabetes patients treated with oral antidiabetic drugs.Method:A total of 27 cases type 2 diabetes patients with poor glycemic control by oral antidiabetic drugs were added to receive once-daily bedtime Insulin Detemir injection.The observation lasted for 3 months.The parameters of the body composition were measured before and after treatment by Inbody 720 body composition analyzer.The parameters included height weight and HbA1c also were measured before and after treatment.Result:After 3 months of treatment,HbA1c was significantly decreased than before treatment(t=5.116,P<0.001).After 3 months of treatment,the percentage of fat was significantly decreased than before treatment(t=2.161,P<0.05).Conclusion:Once-daily Insulin Detemir added to oral antidiabetic drugs in poorly controlled type 2 diabetes patients can improve glycemic control. At the same time weight on a downward trend which muscles no obvious changes,but fat ratio declined markedly.