硝苯地平舌下含服与硝酸甘油静脉滴注治疗高血压急诊患者的疗效

摘要

Objective:To analyze and discuss the effect of sublingual Nifedipine and intravenous Nitroglycerin in hypertension emergency patients.Method:110 hypertension emergency patients in our hospital from March 2013 to May 2015 were selected and randomly divided into the first group and the second group,with each group 55 cases.The first group was given sublingual Nifedipine for treatment,the second group was treated with intravenous Nitroglycerin therapy.The clinical treatment effects of the two groups were compared and analyzed. Result:5 minutes after the treatment,the blood pressure of the first group was lower than before.60 minutes after treatment,the decline of blood pressure in the first group reached a peak.180 minutes after treatment,the blood pressure of the first group presented a raising trend.After treatment,the difference in HR of the first group was statistically significant(P<0.05).5 minutes after the treatment,the blood pressure of the second group was lower than before treatment,the difference was statistically significant(P<0.05).60 minutes after treatment,the decline of blood pressure in the second group reached a peak,then it kept steady.After treatment,the difference in HR of the second group was not statistically significant(P>0.05).The total effective rate of the first group was lower than that of the second group,the difference was statistically significant(P<0.05).The difference in the incidence rate of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion:Intravenous Nitroglycerin therapy in hypertensive emergency patients can achieve therapeutic effect rapidly.It can significantly lower the blood pressure with low incidence rate of adverse reactions.It will not increase the heart break and its efficacy is safe and reliable.Its treatment effect is better than sublingual Nifedipine.It is worthy of clinical promotion and application.%目的：分析探讨硝苯地平舌下含服与硝酸甘油静脉滴注治疗高血压急诊患者的临床效果。方法：选取本院2013年3月-2015年5月收治的110例高血压急诊患者作为研究对象，采用随机数字表法将其分为甲组和乙组，每组55例，甲组给予硝苯地平舌下含服治疗，乙组给予硝酸甘油静脉滴注治疗，分析比较两组临床治疗效果。结果：甲组治疗后5 min血压较治疗前下降，60 min达到下降高峰，180 min呈上升趋势；服药后甲组HR在血压下降时有所增加，比较差异有统计学意义（P<0.05）。乙组治疗后5 min血压低于治疗前，比较差异有统计学意义（P<0.05），60 min达下降高峰后持续稳定；乙组服药后HR比较差异无统计学意义（P>0.05）。甲组治疗总有效率低于乙组，比较差异有统计学意义（P<0.05）。两组不良反应发生率比较差异无统计学意义（P>0.05）。结论：采用硝酸甘油静脉滴注治疗高血压急诊患者，起效快，有利于明显降低血压，不良反应发生率较低，且不会导致心率增快，疗效安全可靠，治疗效果明显优于硝苯地平舌下含服，值得临床推广和应用。