EGFR、KLF4在不同临床分期肺癌组织中的表达变化研究

摘要

Objective: To investigate the epidermal growth factor receptor(EGFR), Kruppel like factor (KLF4) express in different clinical stages of lung cancer tissues.Method: 63 lung cancer patients in our hospital were selected, 63 specimens of lung cancer were collected as study group, 60 specimens of adjacent normal lung tissues (lung edge >5 cm) were collected as control group, EGFR and KLF4 were detected by immunohistochemical method. The differences of EGFR, KLF4 positive express between groups and clinical stage were compared. Result: EGFR positive rate of the study group was significantly higher than the control group, KLF4 positive rate of the study group was significantly lower than the control group(P<0.05). EGFR positive rate of Ⅲ-Ⅳ stage was significantly higher than Ⅰ-Ⅱ stage,KLF4 positive rate of Ⅲ-Ⅳ was significantly lower than Ⅰ-Ⅱ stage(P<0.05). Conclusion:EGFR positive expression in lung cancer tissue is significantly higher, while KLF4 positive expressionin lung cancer tissues is significantly lower,with clinical stage in cancer tissues higher is, EGFR positive rate is higher, KLF4 positive rate is lower.%目的：探讨表皮生长因子受体（EGFR）、Kruppel样因子（KLF4）在不同临床分期肺癌组织中的表达变化。方法：选取本院肿瘤内科肺癌患者63例，手术收集肺癌组织标本63例作为研究组，癌旁正常肺组织（肺癌边缘外>5 cm）标本60例作为对照组，采用免疫组化方法检测EGFR、KLF4表达，比较组间及不同临床分期EGFR、KLF4阳性率的差异。结果：研究组EGFR阳性率明显高于对照组， KLF4阳性率明显低于对照组，差异均有统计学意义（P<0.05）。Ⅲ~Ⅳ期EGFR阳性率明显高于Ⅰ~Ⅱ期肺癌组织，Ⅲ~Ⅳ期KLF4阳性率明显低于Ⅰ~Ⅱ期，差异均有统计学意义（P<0.05）。结论：EGFR在肺癌组织中阳性表达率显著增高，而KLF4在肺癌组织中的阳性表达率显著降低，其中肺癌组织临床分期越高， EGFR阳性率越高，KLF4阳性率越低。