翼状胬肉的新型、高效防治--带蒂角膜缘干细胞转位术

摘要

Objective:To investigate the feasibility of pedicled corneal limbal stem cells grafting for the treatment of pterygium.Method:One hundred and four patients with pterygium admitted to our hospital from March 2012 to June 2014 were selected,they were randomly divided into the treatment group for 58 cases(94 eyes) and the control group for 46 cases(78 eyes).The treatment group was treated with pedicled corneal limbal stem cells grafting,the control group was treated with traditional free autologous stem cell transplantation.The suture removal time,healing time(with conjunctival congestion completely subsided as a quasi),incidence of complications (included graft loss,displacement and necrosis,suture loosening,conjunctival rupture and the adhesion of eyelids),subjective comfort,the recurrence rate one year after operation between the two groups were compared,and the statistical analysis was conducted.Result:There were no statistically significant differences in the incidence of complications and recurrence rate one year after operation between the two groups(P>0.05).The suture removal time and the healing time of the treatment group were significantly shorter than those of the control group,the subjective comfort of the treatment group was significantly better than that of the control group,the differences were statistically significant(P<0.05).Conclusion:Pedicled corneal limbal stem cells grafting is a new method for preventing and controlling of pterygium,is worthy of popularization and application.%目的：探讨带蒂角膜缘干细胞转位术治疗翼状胬肉的可行性。方法：选择2012年3月-2014年6月本院收治的104例翼状胬肉患者，随机将其分为治疗组58例（94眼）和对照组46例（78眼），治疗组应用带蒂角膜缘干细胞转位术，对照组应用传统的游离自体干细胞移植术，对两组患者的拆线时间、痊愈时间（以结膜充血完全消退为准）、并发症发生率（包含移植片丢失、移位、坏死、缝线松脱、结膜裂开、睑球粘连等）、主观舒适度、术后1年复发率等指标的比较，并做统计学分析。结果：两组患者的并发症发生率、术后1年复发率比较差异均无统计学意义（P>0.05）。治疗组的拆线时间、痊愈时间均明显短于对照组，主观舒适度明显优于对照组，差异均有统计学意义（P<0.05）。结论：带蒂角膜缘干细胞转位术是一种新型、高效的翼状胬肉防治方法，值得推广应用。