Objective To investigate the clinical value and the significance of serological detection of herpes simplex virus (HSV) in patients so as to provide basis for the clinical diagnosis. Methods HSV-ⅠIgM/IgG and HSV-II IgM/IgG were detected in 48 cases of patients with clinical symptoms,and 52 cases of asymptomatic patients , and 50 cases of healthy people by enzyme linked immunosorbent assay (ELISA). Results The positive rate in patients with clinical symptoms HSV- Ⅰ IgM typical clinical symptoms was 85.4%, the positive rate of HSV-Ⅰ IgG was 89.6%, the positive rate of HSV- II IgM was 91.7%, the positive rate of HSV- II IgG was 95.8%;the positive rate of HSV- Ⅰ IgM in suspicious patients without symptoms was 23.1%, the positive rate of HSV- Ⅰ IgG was 26.9%, the positive rate HSV- II IgM was 28.8%, the positive rate of HSV- II IgG was 32.7%; the positive rate of HSV-Ⅰ IgM in healthy population was 2%, the positive rate of HSV-ⅠIgG was 4%, the positive rate of HSV- II IgM was 2%, the positive rate of HSV- II IgG 4%. There was a statistical y significant dif erence between the three group the positive rate of IgG ( <0.05), the detection rate is slightly higher than that of IgM ( <0.05), the positive rate of HSV- II IgM/IgG higher than the positive rate of HSV-ⅠIgM/IgG ( <0.05).Conclusion Serum HSV antibody can ef ectively detect asymptomatic infection, and HSV- II antibody detection rate is higher than that of HSV-Ⅰantibody, worthy of clinical application in the diagnosis of HSV infection.%目的探讨血清学指标检测在单纯疱疹病毒（HSV）感染的患者中的临床价值及意义。方法选取我院收治的48例具有典型临床症状的单纯疱疹病毒患者、52例无症状的可疑患者以及50例来院体检的健康人群，采用酶联免疫吸附法（ELISA）检测所选取人群的HSV-Ⅰ以及HSV-ⅡIgM/IgG。结果典型临床症状的单纯疱疹病毒患者HSV-ⅠIgM阳性率为85.4%，HSV-ⅠIgG阳性率为89.6%，HSV-ⅡIgM阳性率为91.7%，HSV-ⅡIgG阳性率为95.8%；无症状的可疑患者HSV-ⅠIgM阳性率为23.1%，HSV-ⅠIgG阳性率为26.9%，HSV-ⅡIgM阳性率为28.8%，HSV-ⅡIgG阳性率为32.7%；健康人群HSV-ⅠIgM阳性率为2.0%，HSV-ⅠIgG阳性率为4.0%，HSV-ⅡIgM阳性率为2.0%，HSV-ⅡIgG阳性率为4.0%。三组检出阳性率之间的差异有统计学意义（<0.05），IgG检出率略高于IgM检出率（<0.05），HSV-ⅡIgM/IgG阳性率高于HSV-ⅠIgM/IgG阳性率（<0.05）。结论血清HSV抗体可有效检测出无症状感染者，且HSV-Ⅱ抗体检出率高于HSV-Ⅰ抗体，值得临床应用于HSV感染的检测诊断。
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