钙调磷酸酶抑制剂在寻常型银屑病中的研究

摘要

钙调磷酸酶抑制剂可阻断钙调磷酸酶的信号通路，抑制T细胞的活化，以往主要作为免疫抑制剂用于器官移植后的免疫调节治疗。近年的研究发现其对一些炎症性皮肤病，如银屑病和特应性皮炎等同样有效，外用疗效接近糖皮质激素却不会导致皮肤萎缩，他克莫司软膏和吡美莫司乳膏有望成为外用糖皮质激素在银屑病治疗中的替代药物。下面以他克莫司及吡美莫司为例概述钙调磷酸酶抑制剂治疗寻常型银屑病的临床疗效、作用机制以及其不良反应。%Calcineurin inhibitors can block calcineurin signaling pathway, thereby suppress Tcellactivation.In the past,itwas used as an immunosuppressant for immunoregulation after organ transplantation. Recent studies have found that they are also ef ective for the treatment of some inflammatoryskin diseases such as psoriasis and atopic dermatitis.Their ef icacyis close to that of corticosteroids but they do notinduce skin atrophy. Tacrolimus ointment and pimecrolimus cream are expected to be an alternative to topical corticosteroids in the treatment of psoriasis. This review presents the clinical ef icacy, mechanism of action and side ef ects of several calcineurin inhibitors in the psoriasis vulgaris.