异甘草酸镁和硫普罗宁治疗化疗后药物性肝损伤的疗效观察

摘要

目的：比较异甘草酸镁与硫普罗宁治疗恶性肿瘤化疔后药物性肝损伤的疗效与不良反应。方法将86例患者随机分为两组，治疗组予异甘草酸镁注射液150mg，对照组组给予硫普罗宁200mg。结果两组患者治疗后临床症状、体征及肝功能指标较治疗前均有明显改善。结论异甘草酸镁治疗化疗药物性肝损害具有肝功能恢复快、不良反应少的优点，临床疗效优于硫普罗宁。%Objective To compare the clinical ef ect and adverse reactions of Magnesium Isoglycyrrhizzinate (MI)and Tiopronin (TP)on hepatic dysfunction induced by chemotherapeutic drugs. Methods 86 patients were randomly divided into two groups, the treatment group was given Magnesium Isoglycyrrhizinate Injection 150mg, control group treated with Tiopronin 200mg. Results After two weeks,the symptoms and liver function parameters of two groups were significantlY improved,No obvious adverse reactions were found in MI group. Conclusion The clinical ef ect of MI on hepatic dysfunction induced by chemotherapeutic drugs is bet er than that of TP.