大剂量丙种球蛋白对脓毒症患儿及免疫功能的影响及临床疗效探讨

摘要

Objective To investigate the changes of immune function parameter and clinical efficacy in the treat-ment of systemic inflammatory response syndrome (SIRS) by HDIG. Methods Seventy-six cases with SIRS were randomly divided into treatment group(39 cases) and control group(37 cases). The two groups were given the routine CD8, CD4/CD8 were measured and clinical efficacy were observed before and after IVIG treatment. Results After IVIG therapy, IgG, CD4, CD8, CD4/CD8 increased significantly (P < 0.05). Compared with control group, the clinical efficacy of treatment group was obvious(χ2=7.52, P < 0.01) and side-effects were not observed. Conclusions WIG treat-ment modulates the immunomechanism in patients with SIRS and improves its prognosis.%目的 观察大剂量静脉注射丙种球蛋白对脓毒症患儿免疫功能的影响及临床疗效.方法 对符合诊断标准的76脓毒症患儿随机分为治疗组(39例)和对照组(37例),在基础治疗相同的情况下,治疗组给予静脉注射丙种球蛋白按每次400～1000 mg/kg,每日1次,连用3 d,并于治疗前后测定IgG、CD4、CD4、CD4/CD4的变化.结果 静脉注射丙种球蛋白治疗前后相比,IgG、CD4、CD8及CD4/CD8明显升高(JP<0.05).与对照组相比,静脉注射丙种球蛋白组疗效显著(χ2=7.52,P<0.01),且无明显不良反应发生.结论 大剂量WIG可调节脓毒症患儿的免疫机制并改善其预后.