慢性乙型肝炎病毒感染增加胰腺癌发病风险研究

摘要

ObjectiveTo evaluate the impact of hepatitis B virus (HBV) infection on pancreatic cancer. Methods A total of 123 patients with pancreatic cancer and 258 age- and sex-matched individuals without malignant diseases were included as controls. Blood samples were tested for hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), hepatitis B e antigen (HBeAg), hepatitis B e antibody (HBeAb) and hepatitis B core antibody (HBcAb). Logistic regression analysis was introduced to estimate odds ratios (OR) and 95%confidence interval (95%CI) of the factors affect the pancreatic cancer risk. Results Multivariable logistic regression model revealed that HBsAg-positive/HBcAb-positive, HBsAb-positive/HBcAb- positive were significantly elevated the risk of pancreatic cancer, with the adjusted OR(95%CI) as 6.33(3.13~12.81),2.27(1.12~4.59),respectively.Conclusions Our results suggest that chronic HBV infection increases pancreatic cancer.%目的：调查乙型肝炎病毒（HBV）感染与胰腺癌发病风险的相关性。方法采用回顾性病例对照研究，病例组为经病理组织学确诊的胰腺癌患者123例，对照组为无恶性肿瘤，其他疾病患者258例。病例组与对照组年龄、性别差异无统计学意义。血清学检测乙型肝炎病毒表面抗原（HBsAg）、乙型肝炎病毒表面抗体（HBsAb）、乙型肝炎病毒e抗原（HBeAg）、乙型肝炎病毒e抗体（HBeAb）以及乙型肝炎病毒核心抗体（HBcAb），logistic回归用于分析胰腺癌发病的危险因素。结果 Logistic回归分析表明，HBV慢性携带及有HBV隐匿性感染是胰腺癌发病的危险因素[OR（95% CI）分别为6.33（3.13~12.81），2.27（1.12~4.59）]。结论慢性HBV感染增加胰腺癌的发病风险。