对于未知来源个体进行族群推断的自动分析系统

摘要

The DNA Ancestry Analyzer Version 1.0,or DAA v1.0,was established based on the probability algorithm,clustering analysis and principal component analysis to infer ancestry for unknown individuals.The basic part of DAA v1.0 was written in Python,R and C;and the front part was written in node.js,HTML,and css.DAA v1.0 can estimate continental ancestry components of unknown individuals and populations.Compared with the previous analysis method,the consistency of DAA v1.0 is 100％,and the efficiency is improved by about 600％.It can calculate the population assignment match probability (AMP),likelihood ratio (LR),population ancestry component and draw the figure of classification of unknown individuals automatically,and has important practical values in the field of human genetics and forensic genetics.%建立一种基于概率算法、聚类分析和主成分分析的DNA族群推断系统(DNA Ancestry Analyzer Version 1.0,简称DAAv 1.0),用于对未知来源个体进行族群推断.DAAv 1.0基础部分用Python语言、R语言、C语言编写;前端部分用nodejs语言、HTML语言、css语言编写.DAAv 1.0可对未知来源个体的族群进行推断,与已有分析方法相比,结果的一致性为100％,运算效率提升了600％.该系统可界面化、自动化地计算DNA来源人的群体匹配概率和似然比值、群体成分,绘制群体归类图,在人类遗传学、法医遗传学等领域有重要的应用价值.