非酒精性脂肪肝患者血清游离脂肪酸与胰岛素抵抗的关系

摘要

Objective To investigate the relationship between serum free fatty acid ( FFA) and insulin resistance (IR) in patients with non-alcoholic fatty liver disease (NAFLD). Methods A total of 118 patients with NAFLD and 103 healthy subjects were enrolled as NAFLD group and control group. Their serum FFA were measured, and homeostasis model assessment-insulin resistance ( HOMA-IR) indices were calculated. Results The level of serum FFA was (752.50 ± 101.42) μmol/L, and HOMA-IR was 1.48 ±0.42 in NAFLD group. The levels of serum FFA and HOMA-IR were higher than those in control group [ (441. 75 ±95.64) μmol/L,0. 67 ±0. 33] (P < 0.01). Serum FFA level was positively correlated with HOMA-IR in NAFLD group (r = 0. 325, P < 0. 05). Conclusions FFA is closely associated with NAFLD, and IR may play a role in the pathogenesis of FFA to NAFLD.%目的 研究非酒精性脂肪肝(NAFLD)患者血清游离脂肪酸(FFA)水平及其与胰岛素抵抗(IR)的关系.方法 测定118例NAFLD患者(NAFLD组)及103名健康体检者(正常对照组)的血清FFA并计算胰岛素抵抗指数(HOMA-IR).结果 NAFLD组血清FFA浓度为(752.50±101.42) μmol/L,HOMA-IR为1.48±0.42,均高于正常对照组[ (441.75 ±95.64) μmol/L,0.67±0.33] (P ＜0.01).NAFLD组FFA与HOMA-IR呈正相关(r =0.325,P＜O.05).结论 FFA与NAFLD密切相关,FFA致NAFLD可能通过IR起作用.