妊娠女性α-L-岩藻糖苷酶、碱性磷酸酶和腺苷脱氨酶活性观察

摘要

目的：妊娠期女性观察血清α-L-岩藻糖苷酶（AFU）、碱性磷酸酶（ALP）及腺苷脱氨酶（ADA）活性的变化及其与妊娠周期的相关性。方法分别检测352例体检正常的不同妊娠期女性（妊娠组，其中早期妊娠210例、晚期妊娠142例）及322例因不孕就诊且尚未妊娠的体检正常的女性（非妊娠组）血清 AFU、ALP、ADA 活性。对所有对象均进行动态监测（早期妊娠组于妊娠第14、22、30及38周分别检测，晚期妊娠组于妊娠第38及40周检测，非妊娠组于就诊时、就诊后第8及24周检测）并做比较。结果妊娠组血清 ALP、AFU 活性明显高于非妊娠组（P ＝0．000），ADA 活性则低于非妊娠组（P ＝0．000）。晚期妊娠组血清 ALP、AFU 活性明显高于早期妊娠组（P ＝0．000），但 ADA 活性两组间差异无统计学意义（P ＞0．05）。对早期妊娠组的动态监测显示，随着妊娠周期的增加，AFU 及 ALP 活性逐渐升高，但 ADA 基本无变化。晚期妊娠组第38周及第40周血清 AFU、ALP、ADA 活性差异均无统计学意义（P ＞0．05）。对非妊娠组的动态监测显示，与就诊时比较，就诊后第8周 ALP、ADA 活性差异有统计学意义（P ＝0．000），就诊后第24周 ADA 活性差异有统计学意义；与就诊后第8周比较，就诊后第24周 ALP、AFU、ADA 活性差异均有统计学意义（P ＜0．05）。结论妊娠期女性血清 AFU 及 ALP 活性明显升高，且随孕周的增加，升高趋势越明显。%Objective To observe the activity changes of alpha-L-fucosidase (AFU),alkaline phosphatase (ALP) and adenosine deaminase (ADA)in pregnant women and their correlations with pregnant period.Methods The activities of AFU,ALP and ADA were determined in 352 pregnant women (210 cases with early-stage pregnancy and 142 cases with late-stage pregnancy)and 322 unpregnant women.Dynamic monitoring was performed (early-stage pregnancy for 14th,22nd,30th and 38th weeks,late-stage pregnancy for 38th and 40th weeks and unpregnancy for 8th and 24th weeks after visiting).Results ALP and AFU were higher in pregnant group than in unpregnant group (P =0.000).The ADA in unpregnant group was higher than that in pregnant group (P =0.000).ALP and AFU in late-stage pregnancy group were higher than those in early-stage pregnancy group (P =0.000),but there was no statistical significance for ADA between the 2 groups (P >0.05).The dynamic monitoring for early-stage pregnancy group showed that AFU and ALP increased with the pregnancy,but there was no change for ADA.There was no statistical significance of AFU,ALP and ADA in late-stage pregnancy group between the 38th week and the 40th week (P >0.05).Dynamic monitoring showed that ALP and ADA in 8th week after visiting were different from the beginning (P =0.000),and there was statistical significance for ADA in the 24th week after visiting.Compared with the 8th week after visiting,there were statistical significance for ALP,AFU and ADA in the 24th week after visiting(P <0.05).Conclusions The serum AFU and ALP in pregnant women increase significantly,and there is relationship with pregnancy.