目的：探讨地诺前列酮栓和缩宫素用于妊娠晚期促宫颈成熟的有效性、安全性，及在降低剖宫产率上的显著作用。方法按对照研究方法，将210例妊娠晚期患者分为两组，观察组90例，应用地诺前列酮栓阴道内放置促宫颈成熟；对照组120例，用小剂量缩宫素静脉滴注，比较两组用药前及用药后6、12 h宫颈Bishop评分、引产成功率、剖宫产率、分娩情况和新生儿结局。结果地诺前列酮栓组给药12 h Bishop评分能提高（2．25±1．40），促宫颈成熟效果达87．7％，用药至分娩时间（15．68±4．46）h ，剖宫产率降至27．8％，两组比较差异有统计学意义（ P＜0．01）。结论地诺前列酮栓是一种安全有效的促宫颈成熟的药物，提高阴道分娩率效果显著。%Objective To evaluate the validity and safety of dinoprostone suppositories and oxytocin for cervi-cal ripening and labor induction ,and to explore their effects on the rate of uterine -incision delivery .Methods Ac-cording to case-control study ,a total of 210 cases of late pregnancy were randomly divided into two groups .Dinopros-tone suppositories were administrated through vagina for setting cervical ripening in observation group ,including 90 cases .Oxytocin of low dose was intravenously injected in control group ,including 120 cases .Bishop scores of cervical of the two groups before and 6 ,12 h after treatment ,the successful rates of induced labor ,rates of cesarean section , delivery and neonatal results were compared between the two groups .Results In observation group ,Bishop score in-creased (2 .25 ± 1 .40) 12 h after administration ,the effect of cervical ripening reached 87 .7% ,medication to delivery time was (15 .68 ± 4 .46)h and rate of cesarean section decreased to 27 .8% .All of these indexes were with significant difference between the two groups (P<0 .01) .Conclusion Dinoprostone suppositories could be a safe and effective drug for promoting cervical ripening ,increasing the rate of vaginal delivery and reducing rate of cesarean section .
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