过敏性疾病患者血清总IgE和过敏原特异性IgE检测分析

摘要

目的：研究过敏性疾病患者的血清总 IgE 浓度和过敏原特异性 IgE（sIgE）强度。方法测定过敏性疾病患者血清总 IgE 浓度和 sIgE 强度，测定外周血嗜酸性粒细胞比例。结果患者血清总 IgE 浓度与外周血嗜酸性粒细胞比例无相关性（r ＝0．398，P ＞0．05），血清总 IgE 和 sIgE 总强度呈正相关（r ＝0．543，P＜0．01）。血清总IgE 与 sIgE 最大强度呈正相关（r＝0．550，P＜0．01），血清总 IgE 与血清 sIgE 种类数呈较弱正相关（r ＝0．329，P＝0．01）。 sIgE 强度相同的患者，其吸入性和食入性抗原的血清总 IgE 浓度差异无统计学意义（P＞0．05），血清总 IgE浓度与患者年龄呈正相关（r＝0．420，P＜0．05）。结论过敏性疾病患者的血清总 IgE 随患者年龄增高而增高，其与 sIgE 总强度和最大强度相关，与 sIgE 种类相关较弱，与抗原的进入途径无关，与嗜酸性粒细胞比例无关。%Objective To investigate the levels of serum total IgE and allergen specific IgE(sIgE) in the pa‐tients with allergic diseases .Methods Serum total IgE and allergen specific IgE in the patients with allergic diseases were detected .The percentage of peripheral blood eosinophils was also detected .Results There was no significant correlation between serum total IgE and percentage of peripheral blood eosinophils(r = 0 .398 ,P> 0 .05) .Significant positive correlation was found between serum total IgE and total intensity of sIgE(r = 0 .543 ,P < 0 .01) .There was positive correlation between serum total IgE and the highest intensity of sIgE (r = 0 .550 ,P < 0 .01) .There was a weak positive correlation between serum total IgE and type number of sIgE(r= 0 .329 ,P= 0 .01) .In the patients with the same intensity of sIgE ,the serum total IgE level had no statistical difference between ingestion allergens and in‐halant allergens .Serum total IgE level was positively correlated with the patient′s age(r = 0 .420 ,P< 0 .05) .Conclu‐sion The serum total IgE level is increased with the age increase in the patients with allergic diseases ,has the corre‐lation with the total intensity of sIgE and weak correlation with the sIgE type and has no correlation with the allergen entering route and the percentage of eosinophils .