糖类抗原125、细胞角蛋白19片段、癌胚抗原在非小细胞肺癌中的临床应用价值

摘要

Objective To evaluate the values of CA125 ,CYFRA21‐1 and CEA in diagnosing of non‐small cell lung cancer (NSCLC) .Methods Serum samples from 130 NSCLC patients ,80 Patients with benign lung disease and 90 healthy donors were collected to detect the level of CA125 ,CYFRA21‐1 and CEA .ROC was generated by Graph‐Pad Prism 5 .We also analyze the diagnosis efficiency of the separate and combined detection .Results ROC area un‐der curve of CA125 ,CYFRA21‐1 and CEA was 0 .836 8 ,0 .842 4 and 0 .785 2 ,separately .The sensitivity of CEA and the specificity of CYFRA21‐1 was the highest in the three serum biomarkers .The accuracy of the combined detection for CYFRA21‐1 and CEA was higher than that of the combined detection for CA125 and CEA .Conclusion Com‐bined determination of CYFRA21‐1 and CEA which is superior to combined detection of CA125 and CEA ,not only had significant values for the diagnosis of NSCLC ,but also can identify the pathological type of NSCLC .%目的：探讨血清标志物糖类抗原125（CA125）、细胞角蛋白19片段（CYFRA21‐1）、癌胚抗原（CEA）在非小细胞肺癌（NSCLC）诊断中的临床价值。方法选择该院NSCLC患者130例、肺部良性疾病者80例，以及同期健康体检者90例（健康对照组），检测血清CA125、CYFRA21‐1、CEA水平，采用Graph Pad Prism 5绘制ROC曲线，分析单独及联合检测时的诊断效能。结果 CA125、CYFRA21‐1、CEA诊断NSCLC的ROC曲线下面积分别为0．8368、0．8424、0．7852。CEA的灵敏度最高，CYFRA21‐1的特异度最高；CYFRA21‐1和CEA联合检测的准确度高于CA125和CEA。结论 CYFRA21‐1和CEA联合检测不仅可用于NSCLC的诊断，还可用于特定病理类型NSCLC的鉴别诊断。