高通量透析对尿毒症维持性血透患者的血脂及 C-反应蛋白的分析研究

摘要

目的 探讨高通量透析对尿毒症维持性血透患者的血脂及C-反应蛋白(CRP)的影响.方法 选择该院尿毒症维持性血透患者40例 ,随机分成观察组及对照组 ,分别行高通量透析和低通量透析治疗 ,每周3次 ,每次4 h ,观察12个月.比较透析前后患者血脂及CRP的变化.结果 观察组患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、CRP都有不同程度的降低 ,差异有统计学意义(P<0 .05).对照组患者 TC、TG、LDL-C、CRP却轻微升高 ,差异无统计学意义(P>0 .05).结论 高通量透析可降低患者血脂及CRP ,改善其微炎性状态及脂质代谢紊乱.%Objective To observe the effect of high flux hemodialysis (HFHD)with FX60 polysulfone dialyser and low flux hemodialysis(LFPD)with F7 polysulfone dialyser on lipids metabolism and high-sensitivity C-reactive protein in patients with maintenance hemodialysis .Methods 40 patients with maintenance hemodialysis were ran-domly divided into HFHD group and LFPD group .The maintenance hemodialysis patients were treated with HFHD using FX60 dialyser or LFPD using F7 dialyser ,three times per week ,4 hours once .After one year of the treatment , high-sensitivity C-reactive protein and total cholesterol ,triacylglycerol and low density lipoprotein cholesterol were detected in patients after treatment .Results In two groups ,the levels of high-sensitivity C-reactive protein and total cholesterol ,triacylglycerol and low density lipoprotein cholesterol before the treatment were the same .In HFPD group ,high-sensitivity C-reactive protein and total cholesterol ,triacylglycerol and low density lipoprotein cholesterol markedly decreased after treatment (P<0 .05) .In LFHD group ,these indices remained unchanged after the dialysis for one year .Conclusion HFHD with FX60 polysulfone dialyser is effective in improving lipid metabolism and micro-inflammation in maintained hemodialysis patients .