泉州地区女性人乳头状瘤病毒基因型与宫颈病变的关系

摘要

目的：探讨泉州地区女性人乳头状瘤病毒（HPV）基因型的感染率，及各基因型与宫颈疾病的关系。方法采用导流杂交基因芯片法对泉州地区5080例女性进行 HPV分型检测，同时，对1154例进行临床病理组织诊断。结果筛查人群中 HPV的总感染率为24．37％（1238／5080），感染率最高为 HPV16型，占总感染数的24．72％（306／1238）。各年龄段 HPV的感染率差异有统计学意义（χ2HPV ＝13．801，P＜0．01）。HPV16在宫颈病理组织中感染率逐级增高（χ2趋势＝214．356，P＜0．01）。结论 HPV 基因型感染与宫颈病变的发生密切相关，其中HPV16、HPV18感染易致宫颈病变进展乃至癌变发生，检测HPV基因型是筛查和监测宫颈病变的有效辅助方法。%Objective To explore the infection rate of human papilloma virus(HPV) genotypes and the rela‐tionship between genotypes and cervical lesions of women in Quanzhou .Methods A total of 5 080 women were col‐lected by liquid‐based method for 21 subtypes of HPV by flow through hybridization and gene chip technology ,which 1 154 cases by clinical pathology diagnosis .Results The positive rate of HPV in 5 080 women was 24 .37% .HPV16 was the most common type ,which is accounted 24 .72% in infected women .There was significant difference in HPV positive rates among the investigated age group (χ2HPV =13 .801 ,P<0 .01) .HPV16 infection rates increased progres‐sively in the grade of histopathological diagnoses(χ2trend=214 .356 ,P<0 .01) .Conclusion HPV genotypes infection is related to the cervical lesions .Among them ,HPV16 ,HPV18 infection is the primary cause of cervical disease pro‐gression and carcinogenesis .HPV detection is a valuable technique for screening and monitoring of secondary cervical lesions .