Objective To explore the effect of HAV infection in allergic disease and Th17 cells effect in the process of HAV infection .Methods From June 2014 to June 2015 ,41 cases of acute HAV infection children and 41 cases of healthy controls in Maternal and Child Health Hospital of Zhangjiakou were chose as research object ,clinical data were retrospectively analyzed in detail ,and serum total IgE and Th17 cells related cytokines level were detected by ELISA .Results Serum total IgE in children with acute HAV infection was lower than healthy controls (P<0 .05) ,and IgE content further reduced with the degree increase of liver injury ;Th17 related cytokines in children with acute HAV infection were higher than healthy controls(P< 0 .05);There was a negative correlation between IgE antibody and IL‐17 levels(r= -0 .533 ,P< 0 .05) .Conclusion Th17 related cytokines in children with acute HAV infection are increased significantly ,which may play a protective role against allergic diseases by reducing the IgE levels .%目的：探讨甲型肝炎病毒（HAV）感染对儿童过敏性疾病的影响及HAV感染过程中Th17所起作用。方法收集2014年6月至2015年6月该院收治的41例急性HAV感染儿童及41例健康对照儿童详细临床资料进行回顾性分析，应用ELISA方法检测血清总IgE及Th17相关细胞因子水平。结果急性HAV感染儿童血清中总IgE水平低于健康对照组（P＜0．05），且随肝脏损伤程度增加IgE水平进一步减少；急性HAV感染儿童Th17相关细胞因子水平高于健康对照组（P＜0．05）；IgE抗体和IL‐17水平呈负相关（r＝－0．533，P＜0．05）。结论急性HAV感染儿童Th17相关细胞因子水平显著升高，可能通过减少IgE水平介导对抗过敏反应的发生。
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