Objective To investigate the effect of dexmedetomidine on TNF‐αin cerebrospinal fluid of patients with intracranial tumor operation in alpha and IL‐8 .Methods 82 cases of intracranial tumor patients treated in the hospital were selected as the research object from June 2014 to August 2015 using the numbering averaging method to divide them into two groups ,that is ,the observation group and the control group ,with 41 cases in each group .The fast sequential method carries on the induction of anesthesia ,the observation group was given load for 1 .0 μg/kg dexmedetomidine ,fentanyl dosage to 3 .0 μg/kg ,1 .2 mg/kg propofol ,rocuronium 1 .0 ng/kg ;while the control group patients was only given 0 .9% NS .Patients in both the two groups after 2 minites of drug were given endotracheal in‐tubation and mechanical ventilation .The changes of and TNF‐α levels and IL‐8 in serum of two groups of patients were analyzed by T1 ,T2 ,T3 T4 and T5 .Results The serum levels of TNF‐α in patients with T3 ,T4 ,T4 and T5 were significantly lower than those of the control group ,and the IL‐8 levels of the patients in the observation group were significantly lower than those of the control group ,and the observation group was significantly different from the control group .Conclusion The peri operation period in patients with intracranial tumor surgery that was given dexmedetomidine can reduce the content of serum TNF‐α and IL‐8 ,morever ,with the body′s response of stress re‐duced .%目的：分析右美托咪啶对颅内肿瘤手术患者脑脊液中肿瘤坏死因子‐α（T N F‐α）和白细胞介素‐8（IL‐8）的影响。方法选取该院2014年6月至2015年8月收治的82例颅内肿瘤患者，采用随机数字表法分为观察组和对照组，每组41例。麻醉诱导中，观察组静脉泵注右美托咪啶1．0μg／kg ，静脉推注芬太尼3．0μg／kg、丙泊酚1．2 mg／kg、罗库溴铵1．0 ng／kg ；对照组给予0．9％生理盐水，其余药物同观察组，2 min后气管插管并行机械通气。对比分析2组不同时间点T1（诱导之前）、T2（诱导之后）、T3（切割皮时）、T4（手术进行1 h后）及T5（手术结束时）血清中TNF‐α和IL‐8水平的变化情况。结果观察组在T2、T3、T4及T5时血清中的TNF‐α和IL‐8水平均明显低于对照组（tTNF‐α＝12．12、13．73、15．21、15．07，tIL‐8＝10．21、12．85、8．72、9．01，P＜0．05）。结论右美托咪啶可降低颅内肿瘤手术患者血清T N F‐α和IL‐8水平，减轻机体应激反应。
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