Objective To detect the change of serum CT‐1 and IL‐6 levels in the patients with obstructive sleep apnea‐hypopnea syndrome (OSAHS) and to investigate the relation between the CT‐1 and IL‐6 with the disease condition of OSAHS .Methods Serum CT‐1 and IL‐6 levels were detected and compared between 58 patients with OSAHS and 50 healthy controls .Their relation with OSAHS was analyzed .Results The serum CT‐1 and IL‐6 levels in the OSAHS group were higher than those in the control group ;the serum CT‐1 and IL‐6 levels was positively cor‐related with AHI ,and the IL‐6 level was negatively correlated with LSaO 2 ;serum CT‐1 had no correlation with IL‐6 ;meanwhile serum CT‐1 and IL‐6 levels had statistical difference among mild ,moderate and severe OSAHS ( P<0 .05) ,while had no statistical difference in the distributions of the age ,sex and whether smoking (P > 0 .05) ,but which were relatively higher in the OSAHS patients with over body weight ,drinking or hypertension .Conclusion The serum CT‐1 and IL‐6 levels can be used to reflect the severity of OSAHS .%目的：检测阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血清心肌营养素‐1（CT‐1）和白细胞介素‐6（IL‐6）的变化，探讨 CT‐1和 IL‐6与 OSAHS 患者病情的相关性。方法设置 OSAHS 组（n ＝58）和对照组（n＝50），测定并比较血清 CT‐1和 IL‐6的变化，分析其与 OSAHS 的相关性。结果 OSAHS 组血清 CT‐1和 IL‐6水平均要高于对照组；OSAHS 患者血清 CT‐1与 AHI 呈正相关；IL‐6与最低血氧饱和度呈负相关；而血清 CT‐1和IL‐6间无相关性；同时血清 CT‐1和 IL‐6在轻度、中度、重度 OSAHS 患者中差异有统计学意义（P ＜0．05）；血清CT‐1和 IL‐6在年龄、性别、是否吸烟等分布上差异无统计学意义（P ＞0．05），而在体质量超重、饮酒或高血压的OSAHS 患者中相对较高。结论血清 CT‐1和 IL‐6可用于反应 OSAHS 患者病情的严重程度。
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