Objective To explore the clinical significance of changes of serum albumin, IL-6 and CRP levels in patients with moderate and severe craniocerebral injury.Methods 90 patients with moderate and severe traumatic brain injury were divided into moderate injury group (31 cases), severe injury group (59 cases);fatality group (21 cases) and survival group (69 cases).Detections of serum albumin, IL-6 and CRP levels at different times during admission and hospitalization were done.Results The average serum albumin level in the severe injury group was higher than that in the moderate injury group, the difference was statistically significant (P<0.05).The average serum albumin level in the fatality group was higher than that of survival group, the difference was statistically significant (P<0.05).The IL-6 and CRP levels of severe trauma group were significantly higher than those in the IL-6 and CRP levels at the time of admission and in the period of hospitalization, and the differences were statistically significant (P<0.05).The IL-6 and CRP levels in the case of fatality group were significantly higher than those in the survival group at the time of admission and during the period of hospitalization.The differences were statistically significant (P<0.05) (CRP).Conclusions During the period of hospitalization, the serum albumin level in patients with moderate and severe traumatic brain injury is decreased, and the level of IL-6 and C reactive protein is increased, and the changes of the above indexes are helpful to judge the prognosis of patients with moderate and severe craniocerebral injury.%目的 探讨血清白蛋白、IL-6和CRP水平改变在中重度颅脑损伤患者中的临床意义.方法 选择90例中重度颅脑损伤患者,分为中度损伤组(31例)、重度损伤组(59例)及病死组(21例)、存活组(69例).检测所选患者入院时、住院期间不同时间的血清白蛋白、IL-6和CRP水平.结果 重度损伤组住院期间平均血清白蛋白水平高于中度损伤组,差异有统计学意义(P<0.05);病死组住院期间平均血清白蛋白水平高于存活组,差异有统计学意义(P<0.05).重度损伤组入院时和住院期间IL-6、CRP水平分别高于中度损伤组入院时和住院期间IL-6、CRP水平,差异有统计学意义(P<0.05);病死组入院时和住院期间IL-6、CRP水平分别高于存活组入院时和住院期间IL-6、CRP水平,差异有统计学意义(P<0.05).结论 中重度颅脑损伤患者住院期间血清白蛋白水平下降,IL-6和CRP水平升高,观察上述指标水平的变化有助于判断中重度颅脑损伤患者预后.
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