滋阴益气中药减少老年患者肾病综合征复发的疗效观察

摘要

目的 探讨滋阴益气中药减少老年患者肾病综合征复发的临床疗效.方法 选择2012年12月至2014年8月在石家庄肾病医院接受治疗的初诊90例老年肾病综合征患者,按照随机数字表法分为治疗组和对照组,每组45例,对照组采用西医常规治疗,治疗组在对照组的基础上增加滋阴益气汤口服治疗,观察患者用药后的临床疗效和18个月的复发情况,定期检测尿常规、24 h尿蛋白定量、血清清蛋白、血脂7项、肌酐等.结果 治疗6个月后,治疗组总有效率为90.48%,对照组总有效率为60.09%,2组比较差异有统计学意义(χ2=5.973,P=0.015).治疗12、18个月后,治疗组患者的复发率均低于对照组,差异有统计学意义(P<0.05).治疗后2组患者的尿素氮、24 h尿蛋白定量、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、血肌酐等均低于治疗前,而血清总蛋白、血清清蛋白、高密度脂蛋白胆固醇高于治疗前,且治疗组优于对照组,差异有统计学意义(P<0.05).结论 滋阴益气中药可提高老年患者肾病综合征的临床疗效,显著降低患者的复发率,改善尿常规、24 h尿蛋白定量、清蛋白、血脂7项、肌酐等指标.%Objective To study the curative effect of traditional Chinese medicine with nourishing yin and tonifying qi to reduce recurrence of elderly patients with nephrotic syndrome.Methods 90 elderly patients with nephrotic syndrome in our hospital from December 2012 and August 2014 were divided into the treatment group(45 cases) and control group(45 cases) according to random number table method.The control group was treated by routine western medicine,and the treatment group was treated by traditional Chinese medicine with nourishing yin and tonifying qi on the basis of conventional western medicine treatment.The clinical outcome and the relapse on the end of 18 months were observed.The regular routine urine,24 h urinary protein,serum albumin,seven quantitative blood fat index and serum creatinine were detected.Results After 6 months treatment,the total effective rate was 90.48% in treatment group,and the control group was 60.09% in control group,with the difference statistically significant(χ2=5.973,P=0.015).After 12 months and 18 months treatment,the recurrence rates in treatment group were lower than the control group,with the difference statistically significant(P<0.05).The levels of urea nitrogen,24 h urine protein quantitative,total cholesterol,triglyceride,low-density lipoprotein cholesterol and serum creatinine after the treatment were lower than before the treatment,the levels of serum total protein,serum albumin and high-density lipoprotein cholesterol were higher than before the treatment,and the treatment group was better than that the control group,with the difference statistically significant(P<0.05).Conclusion Traditional Chinese medicine with nourishing yin and tonifying qi can improve the curative effect of elderly patients with nephrotic syndrome,significantly reduce the recurrence rate of patients,improve the routine urine,24 h urinary protein,serum albumin,seven quantitative blood fat index and serum creatinine.