青霉胺联合温阳化瘀法及中药泡浴治疗系统性硬皮病的临床效果分析

摘要

目的 研究青霉胺联合温阳化瘀法及中药泡浴治疗系统性硬皮病的临床效果.方法 选取2014年9月至2015年7月收治的122例系统性硬皮病患者作为研究对象,以随机数字表进行分组试验,对照组61例患者采取青霉胺治疗,观察组61例患者在对照组治疗基础上联合温阳化瘀法及中药泡浴治疗,对比两组患者治疗后临床疗效、皮肤硬度积分、关节痛与关节功能积分、药物不良反应情况.结果 观察组患者治疗后总有效率高达98.36%,明显高于对照组的88.52%,差异有统计学意义(P<0.05);观察组药物不良反应率为1.64%,低于对照组的13.11%,差异有统计学意义(P<0.05);观察组患者治疗后皮肤硬度积分、关节痛与关节功能积分均优于对照组,差异均有统计学意义(P<0.05).结论 青霉胺联合温阳化瘀法及中药泡浴治疗系统性硬皮病临床效果良好,患者症状明显改善,药物不良反应少,安全性高,可于临床推广应用.%Objective To investigate the clinical effect of penicillamine combined with Wenyanghuayu method and Chinese traditional medicine bath in the treatment of systemic scleroderma.Methods One hundred and twenty-two cases of systemic scleroderma in our from September 2014 to July 2014 were selected as the research subjects and grouped by the random number table for conducting the experiment.The control group (61 cases) took the penicillamine treatment,while on this basis the observation group (61 cases) was treated by Wenyanghuayu method and Chinese medicine bath.The clinical effects,skin hardness score and joint pain and joint function score,and adverse drug reactions after treatment were compared between the two groups.Results The total effective rate in the observation group was up to 98.36%,which was significantly higher than 88.52% in the control group,and the difference was statistically significant (P<0.05);the adverse drug reaction rate in the observation group was 1.64%,which was lower than 13.11% in the control group,the difference was statistically significant(P<0.05);the skin hardness score,and joint pain and joint function score after treatment the observation group were obviously superior to those in the control group,the difference was statistically significant(P<0.05).Conclusion Penicillamine combined with Wenyanghuayu method and Chinese traditional medicine bath for treating systemic scleroderma has good clinical effect,the symptoms are significantly improved with less adverse drug reactions and high safety,which can be promoted and applied in clinic.