Cis-Dichlorodiamine Platinum (II) (NSC-119 875):No Decrease in Toxicity by Combined Treatment with Penicillamine in Rhesus Monkeys.

摘要

Cis-dichlorodiammine platinum (II) (NSC-119 875):No decrease in toxicity by combined treatment with penicillamine in Rhesus monkeys. It was hoped that the combination of cis-dichlorodiammine platinum (II) with penicillamine, a chelating agent,would reduce the toxicity of the former agent. Four monkeys,however,that were treated daily for 5consecutive days with a combination of cis-dichlorodiammine platinum (II) 1mg/kg iv and penicillamine 100mg/kg po,developed more severe morbidity than monkeys that received only cis-dichlorodiammine platinum (II). Penicillamine,therefore,does not reduce the toxicity of cis-dichlorodiammine platinum (II).