妊娠剧吐与胎盘功能障碍性疾病的相关性研究

摘要

Objective To investigate the correlation of hyperemesis gravidarum and placental dysfunction disorders.Methods By the method of prospective cohort study,2 010 pregnant women accepted first antenatal care at our hospital from Jan.2013 to Dec.2015 were selected as the study objects,then they were divided into three groups of no hyperemesis gravidarum,mild hyperemesis gravidarum and severe hyperemesis gravidarum among prenatal examinations.For pregnant woman with mild and severe hyperemesis gravidarum,the correlations of placental dysfunction disorders (gestational hypertension,preeclampsia,miscarriage and stillbirth),neonatal outcomes (birth weight,small for gestational age,low birth weight,Apgar score at 5 min after delivery) and hyperemesis gravidarum were analyzed.Results There were no significant differences of hyperemesis gravidarum on placental dysfunction disorders and neonatal outcomes (P>0.05).Conclusion There are no obvious correlation between placental dysfunction disorders,neonatal outcomes and hyperemesis gravidarum.%目的 探讨妊娠剧吐与胎盘功能障碍性疾病及新生儿结局相关性.方法 采用前瞻性队列研究,选取2013年1月至2015年12月进行初次产前检查的2 010例孕妇为研究对象,通过产前检查将其分成无妊娠剧吐、轻度妊娠剧吐、重度妊娠剧吐3组,针对轻度妊娠剧吐和重度妊娠剧吐孕妇,分析孕妇胎盘功能障碍性疾病(妊娠高血压、子痫前期、流产、死胎)、新生儿结局(出生体质量、小于胎龄儿、低出生体质量、产后5 min Apgar评分、孕周)同妊娠剧吐的相关性.结果 重度妊娠剧吐组、轻度妊娠剧吐组和无妊娠剧吐组的胎盘功能障碍性疾病和新生儿结局差异无统计学意义(P>0.05).结论 妊娠剧吐与胎盘功能障碍性疾病和新生儿结局并无明显关联.