Objective To detect the levels of serum amyloid A (SAA) in the patients with cerebral hemorrhage ,and investigate the association between SAA and cerebral hemorrhage .Methods A total of 113 patients with cerebral hemorrhage diagnosed by MRI or CT were selected into study group ,including 47 cases of mild condition ,34 cases of moderate condition ,32 cases of severe condition ,and 118 healthy people were recruited into control group .Immunofluorescence assay was applied to detect the levels of SAA .Levels of SAA in the two groups were contrasted .Results The levels of SAA in the study group and control group were (95 .47 ± 89 .54) ,(6 .99 ± 1 .84)mg/L ,SAA in the study group was significant higher than that of the control group (P=0 .001) . The levels of SAA in patients with mild condition ,moderate condition ,severe condition were(13 .17 ± 8 .81) ,(123 .15 ± 69 .60) , (189 .90 ± 59 .35)mg/L ,patients in different condition were significant different (P<0 .05) .The results of receiver operating char-acteristic curve analysis showed that the area under the curve (AUC) was at its maximum 0 .891 when value of cut-off point was 10 .40 mg/L .It showed that SAA was suitable for cerebral hemorrhage screening ,but it had a lower diagnostic efficiency than D-di-mer .Conclusion There is an intimate relationship between patient′s condition and the levels of SAA .It implies that SAA might be a risk factor of cerebral hemorrhage .%目的 检测脑出血患者血清淀粉样蛋白A(SAA)水平,探讨脑出血对患者血清中SAA水平的影响.方法 收集经M RI或C T确诊的脑出血患者113例纳入研究组,分为轻度组47例,中度组34例,重度组32例;体检健康者118例纳入对照组.比较各组患者血清中S A A表达水平的差异.结果 研究组与对照组血清中S A A表达水平分别为(95.47±89.54)、(6.99±1.84)mg/L,研究组明显高于对照组,差异有统计学意义(P=0.001).轻度组、中度组、重度组SSA表达水平分别为(13.17±8.81)、(123.15±69.60)、(189.90±59.35)m g/L,轻度组患者血清中S A A水平明显低于中度组,中度组患者血清中S A A水平又明显低于重度组,差异均有统计学意义(P<0.05).经受试者工作特征曲线分析,当SAA临界值为10.40 mg/L时,曲线下面积达最大值0.891,灵敏度为78.60%,特异度为94.10%,说明具有较好的诊断效率,但仍不及D-二聚体(AUC=0.958,灵敏度为87.5%,特异度为96.6%).结论 SAA水平与脑出血有关,提示其可能是脑出血的一个危险因素.
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