血清胃泌素17及胸苷激酶1的水平变化在胃癌诊断中的价值研究

摘要

Objective Investigate the changes of serum G17 and TK1 levels in patients with gastric cancer, and analyze its value in diagnosis.Methods A total of 120 cases of patients with stomach disease were select-ed,which were treated in hospital from June 2015 to June 2016.Among them,45 cases of gastric cancer pa-tients were recorded as group A,38 cases of gastric ulcer patients were recorded as group B,37 cases of chronic gastritis patients were recorded as group C.The levels of serum G17 and TK1 were compared among the three groups,and the diagnostic value for gastric cancer was analyzed.Results In the terms of serum CEA and CA19-9,the patients of group A were significantly higher than those of group B and group C,and the patients of group B were significantly higher than those of group C(P<0.05);In the terms of serum G17 and TK1,the patients of group A were significantly higher than those of group B and group C,and the patients of group B were significantly higher than those of group C(P< 0.05);Pearson correlation analysis showed that there were significant positive correlations between serum G17,TK1 and CEA,CA19-9 in patients of group A(r=0.628,0.646,0.583,0.602;P=0.000,0.000,0.000,0.000),and there was also a significant positive correla-tion between serum G17 and TK1 in patients of group A(r=0.598,P=0.000).Compare to the serum G17, TK1 alone for the diagnosis of gastric cancer,the sensitivity of the combined diagnosis of two indicators signif-icantly increased(χ2= 5.204,P= 0.015).Conclusion Serum G17 combined with TK1 for the diagnosis of gastric cancer,can effectively improve the accuracy,w hich has an important clinical significance for the identi-fication of gastric cancer and other gastric diseases.%目的 探讨胃癌患者血清胃泌素17(G17)、胸苷激酶1(T K1)水平变化在胃癌诊断中的价值.方法 选择2015年6月至2016年6月治疗的120例胃部疾病患者作为研究对象,其中45例胃癌患者记为A组,38例胃溃疡患者记为B组,37例慢性胃炎患者记为C组.比较3组患者的血清G17、T K1水平,并分析其对于胃癌的诊断价值.结果 经比较发现,A 组患者的血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)水平明显高于B组、C组,B组患者的血清CEA、CA19-9水平亦明显高于C组,组间比较差异均有统计学意义(P<0.05).A组患者的血清G17、T K1水平明显高于B组、C组,B组患者的血清G17、T K1水平亦明显高于C组,组间比较差异均有统计学意义(P< 0.05).经 Pearson 相关性分析发现,A 组患者的血清 G17、T K1均与CEA、CA19-9间呈正相关(r=0.628,0.646,0.583,0.602;P=0.000,0.000,0.000,0.000),血清G17与 T K1间亦呈正相关(r=0.598,P=0.000);同血清G17、T K1水平单独用于胃癌检测相比,二者联合检测的灵敏度显著上升(χ2=5.204,P=0.015).结论 血清G17、T K1联合用于胃癌的诊断,能够有效提高准确性,对于胃癌和其他胃部疾病的鉴别具有重要的临床意义.