儿童重症结核病相关危险因素分析

摘要

目的 调查分析与儿童重症结核病相关的危险因素.方法 回顾性研究2002年1月至2010年12月北京儿童医院住院病人中诊断为结核病的0～17岁儿童结核病病例,并对可能影响儿童患重症结核病的危险因素进行单因素及多因素的logistic回归分析.结果 年龄、卡介苗接种、结核病接触史及PPD试验4项研究因素P值小于0.05,OR值及95％可信区间分别为:0.716(0.650 ～0.789),0.606(0.468 ～0.784),1.483(1.131～1.945)和0.417 (0.317 ～0.549).结论 小于1岁、未接种卡介苗、有结核病密切接触史及PPD试验结果阴性是儿童重症结核病的独立危险因素.%Objective To analysis risk factors of severe tuberculosis (TB) in children. Method The retrospective study of children under 17 year of age admitted to Beijing Children' s Hospital for TB from January 2002 to December 2010 was conducted. The univariate and multivariate logistic regression analysis were used to analyze the relation between risk factors and severe tuberculosis in children. Results The P value of four factors association with severe tuberculosis including age, BCG vaccination, history of exposure to active tuberculosis patient and PPD tuberculin test were less than 0. 05, the OR value and 95% CI were 0.716 (0.650-0.789), 0.606 (0.468 -0.784), 1.483 (1.131-1.945) and 0.417 (0.317-0.549) respectively. Conclusion The results indicate that the age less than 1 year old, non-BCG vaccinated, close contact with active tuberculosis patient and PPD tuberculin skin test negative are independent risk factors with severe tuberculosis in children.