健康体检人群幽门螺杆菌感染程度与血清胃蛋白酶原水平的关系

摘要

目的 了解健康体检人群的幽门螺杆菌(Hp)感染程度并探讨与血清胃蛋白酶原(PG)的关系.方法 用13C尿素呼气试验(UBT)检测438名健康体检者,用TRFIA法检测血清PGⅠ、PGⅡ水平,并分析与Hp感染程度的关系.结果 体检人群Hp感染率为47.95％；女性在Hp(++++)组中Hp感染程度显著高于男性.Hp阳性组血清PGⅠ、PGⅡ水平显著高于Hp阴性组,而PGⅠ/PGⅡ则显著低于Hp阴性组,PG异常检出率在两组间差异显著.Hp感染程度与血清PG水平分析可见,随着UBT值增加,PGⅠ、PGⅡ水平上升,而PGⅠ/PGⅡ则明显下降.结论 健康体检人群中,有较高的Hp感染率和PG异常率,应引起足够重视.反映Hp感染程度的UBT值与血清PG水平及PG异常率密切相关,Hp与PG水平检测相结合可以作为健康体检人群的普查战略以筛查胃病高危人群.%Objective To investigate the degree of infection of Helicobacter pylori (Hp) in the health check-up group,and to explore the relationship between degree of Hp infection and levels of serum pepsinogen (PG).Methods 438 cases of health check-up people were chosen to perform the 13C urea breath test (UBT) to detect the Hp infection.The serum PG level was detected by TRFIA.Results The infection rate of Hp in health people was 47.95％.The degree of Hp infection (++++) in female was remarkably higher than that of male.The serum levels of PGI and PGⅡ in Hp positive group were remarkably higher than that in Hp negative group,and the ratio of PGⅠ to PGⅡ was remarkably lower.The rates of abnormal PG also had significant differences between two groups.The results also showed that the levels of PGⅠ and PGⅡ were increased as UBT value increased,and the ratio of PGⅠ to PGⅡ was remarkably decreased.Conclusion The Hp infection rate and PG abnormality rate were relatively high in the health check-uppeople,and it should cause attention.The combined detection of Hp infection and PG tests could be used in the health check-up people to screen high risk group with gastric diseases.