两种质子泵抑制剂静注辅助常规对症干预对急性非静脉曲张性上消化道出血患者PCV、BUN水平及不良反应风险的影响

摘要

目的 研究埃索美拉唑和奥美拉唑两种质子泵抑制剂静注辅助常规对症干预对急性非静脉曲张性上消化道出血患者PCV、BUN水平及不良反应风险的影响.方法 选择2013年11月至2015年11月在我院接受治疗的ANVUGIB患者120例.分为对照组(n =60)和观察组(n=60).对照组患者在常规对症干预治疗的基础上给予奥美拉唑注射液治疗,观察组患者在常规对症干预治疗的基础上给予埃索美拉唑注射液治疗,比较两组患者的临床疗效、临床指标和不良反应.结果 观察组患者的显效率为63.33％,有效率为30.00％,无效率为6.67％,总有效率为93.33％;对照组分别为60.00％、31.67％、8.33％和91.67％;两组患者的止血时间、住院时间、输血量、PCV及BUN水平相近,以上差异无统计学意义(P＞0.05).观察组患者不良反应的总发生率为8.33％,对照组患者不良反应的总发生率为16.67％,差异有统计学意义(P＜0.05).两组患者的主要不良反应为腹胀和头痛.结论 埃索美拉唑和奥美拉唑两种质子泵抑制剂静注辅助常规对症干预对ANVUGIB患者的疗效相当,但埃索美拉唑的不良反应较低,安全性较好.%Objective To investigate the efficacies and adverse risks of esomeprazole and omeprazole of proton pump inhibitors in symptomatic intervention of acute non variceal upper gastrointestinal bleeding.Methods A total of 120 cases of patients with acute non variceal upper gastrointestinal bleeding who were treated in our hospital were selected from November 2013 to November 2015.They were divided into control group and observation group based on the random number table method,each group had 60 cases.The control group was given omeprazole injection on the basis of conventional symptomatic treatment.The observation group was given esomeprazole injection on the basis of conventional symptomatic treatment.Clinical efficacy,clinical indicators and adverse risks were compared between two groups.Results In observation group,there were 63.33％ rated highly effective,30.00％ effective,and 6.67％ with no effect.The total effective rate was 93.33％.In control group,there were 60.00％ highly effective,31.6％ effective and 8.33％ no effect;and total effective rate was 91.67％.Patients' hemostasis time,hospitalization time,blood transfusion,PCV and BUN levels showed no statistical differences (P ＞ 0.05).The observation group had 8.33％ adverse reactions whereas control group had 16.67％ adverse incidence rate,the difference was statistical significant(P ＜ 0.05).The major adverse reactions were abdominal distension and headache in both groups.Conclusion Esomeprazole and omeprazole proton pump inhibitors in conventional symptomatic intervention of acute non variceal upper gastrointestinal bleeding are similar effective.Esomeprazole proton pump inhibitor has lower adverse risk and is safer to use.