内源乳化法制备2，4-D／海藻酸钠／羽毛蛋白微球及其缓释性能

摘要

2,4-D/sodium alginate/feather protein microspheres were prepared by emulsification /internal gelation method.The influence of the mass ratio of feather protein to sodium alginate , volume ratio of the oil to water , and the content of nano-calcium carbonate on the morphology , loading content and slow-re-lease performance of the microspheres were studied .The results showed that the optimized conditions was:the mass ratio of sodium alginate to feather protein was 100∶30 , the volume ratio of the oil to water was 3∶1, the dosage of calcium carbonate was 0.2 g.Prepared with the optimized system the 2,4-D SA/FP microspheres , had the loading content of 2 ,4-D was 3.68%, with uniform distribution and smooth surfaces with spherical geometry , and had a good slow release performance .%以海藻酸钠（Sodium Alginate， SA）和羽毛蛋白（Feather Protein， FP）为载体材料，2，4-二氯苯氧乙酸（2，4-D）为模型药物，采用内源乳化法制备了2，4-D／SA／FP复合微球，并考察了羽毛蛋白与海藻酸钠的质量比、油水（体积）比、纳米碳酸钙用量对载药微球的形貌、载药性能和缓释性能的影响．结果表明， V（油）∶V（水）＝3∶1，羽毛蛋白为海藻酸钠质量的30％，纳米碳酸钙用量为0.2 g时，所制得微球球形度较好，粒径分布较均匀，载药量为3.68％，具有良好的缓释性能．