microPET大鼠脑模板研究

摘要

Small animal positron emission tomography(PET)technology is widely used in neuroscience studies.In order to facilitate the analysis between different subjects or between repeat scans of the same subject,FDG-PET template of rat brain was constructed using two methods.Twenty Sprague-Dawley rats were included for template construction.The MR-PET template and synPET template of rat brain were constructed respectively,and the accuracy of the two template registration were evaluated.The results showed that the average error when using MR-PET template for registration was 1.818 mm,and the error range was 1.093-2.752 mm, while the average error when using synPET template for registration was 2.009 mm,and the error range was 1.615 mm-2.445 mm.Therefore,FDG-PET rat brain template constructed based on M R rat brain template have high registration accuracy than the synPET template.%小动物正电子发射断层扫描(PET,positron emission tomography)技术被广泛应用于各种神经科学的研究.为了便于进行不同个体或同一个体重复扫描数据的分析,通过对不同PET 脑模板制作方法的比较,制作一个大鼠大脑的FDG-PET 模板.实验中20只健康SD(Sprague dawley)大鼠大脑的PET扫描数据被纳入研究,分别建立了大鼠的M R-PET脑模板和synPET 脑模板,同时比较了以这两种模板为标准进行配准时的配准精度.结果表明:使用M R-PET 模板进行配准时的平均误差为1.818 mm,误差范围为1.093~2.752 mm;而使用synPET 模板进行配准时的平均误差为2.009 mm,误差范围在1.615~2.445 mm.基于M R大鼠脑模板制作的M R-PET 模板的配准误差要小于synPET模板.