The synthesis of the complex Zn(ofo)2 (H2O) · 2H2O is reported. Its crystal structure is presented and discussed. The title compound crystallizes in the triclinic space group P- 1 with a= 9. 306 (1) (A), b= 11.331 (1)(A), c =17. 787(2)(A),α=92. 667(1)°,β=94. 898(2)°,γ=92. 071(2)°,V=1865. 1(3)(A)3 ,Z=2, and Dc = 1. 496 mg · m-3.The Zn( Ⅱ ) ion is in a slightly distorted square pyramid environment of oxygen atoms. The IR bands of carboxylic and ketonic group at 1 713 and 1 622 cm-1 , respectively, shift to 1 620 and 1 584 cm-1 in the coordination compound. Thermo-gravimetric(TG) and its differential(DTG) for ofo and the coordination compound are carried out and explained in detail. Both ligand and the complex are assayed against gram-positive and gram-negative bacteria by in vitro doubling dilutions method, the complex shows the same minimal inhibitory concentration(MIC) as the corresponding ligand against S. Aureus, M. Lutens, E. Coli and P. Aeruginosa.%合成了以氧氟沙星(ofloxacin,ofo)为配体的锌(Ⅱ)配合物Zn(ofo)2 (H2O)·2H2O,报道了锌配合物的单晶结构:三斜晶系,P-1空间群,晶胞参数为a=9.306(1)(A°),b=11.331(1)(A°),c=17.787(2)(A°),α=92.667(1)(A°),β=94.898(2)°,γ=92.071(2)°,V=1865.1(3)(A°)3,Z=2,Dc=1.496 mg·m-3,畸变的四方锥形配位几何构型,其中锥顶上的氧原子来自水分子,锥底的4个氧原子来自两个氧氟沙星的羧酸根和酮基;探讨了该配合物的红外光谱、紫外-可见光谱、固体荧光光谱性质,对配合物的热稳定性进行了研究;并利用液体稀释法测定了药物配体和配合物对两种革兰氏阳性菌和两种革兰氏阴性菌的体外抑制活性.结果表明配合物与药物配体的抗菌活性相近.
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