p53非依赖性信号通路在DNA损伤致细胞凋亡中的研究进展

摘要

p53 is considered as the "master regulator" in DNA damage-induced cell apoptosis. However,p53 is the most frequently mutated gene in human cancers ( more than 50% ) . Thus the research of p53-independent pathway in cell apoptosis may ultimately provide new therapeutic opportunities for many cancers. It has been shown that Caspase 2, p73, p63, and NF-κB-related signaling pathways are involved in DNA damage-induced,p53-independent cell apoptosis. This article reviews the recent research progress in these signaling pathways.%p53在DNA损伤诱导细胞凋亡中发挥关键作用,但p53基因在大多数肿瘤细胞中易发生突变,突变率可超过50％.目前研究发现,p73、p63、Caspase 2、NF-κB等蛋白介导的信号通路能够在p53非依赖的DNA损伤诱导细胞凋亡中发挥作用.因此,有必要对p53非依赖信号通路近年来的研究进展作一综述,为癌症治疗提供新的思路.